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Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study
Danni Zheng1,2, Hisatomi Arima1,2,3, Shoichiro Sato1
1Division of Neurology and Mental health, The George Institute for Global Health, Sydney, New South Wales, Australia.
Plos One
|February 10, 2016
Summary
Exposure to cold ambient temperatures significantly increases the risk of acute intracerebral hemorrhage (ICH). Even short-term exposure to low temperatures, particularly below 10°C, elevates the likelihood of experiencing ICH.
Area of Science:
- Neurology
- Environmental Health
- Epidemiology
Background:
- Acute intracerebral hemorrhage (ICH) incidence rises during colder months.
- The precise relationship between ambient temperature and ICH risk remains unclear.
- This study quantifies the association between hourly ambient temperature and ICH risk.
Purpose of the Study:
- To determine the hourly association between ambient temperature and the risk of acute intracerebral hemorrhage (ICH).
- To quantify the magnitude of risk increase for ICH related to low ambient temperatures.
Main Methods:
- Utilized data from 1997 participants in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2).
- Linked individual hourly temperature data to participant baseline information.
- Employed case-crossover analyses with a distributed lag non-linear model (24h lag) to assess temperature-ICH risk association.
Main Results:
- Low ambient temperatures (≤10°C) were linked to elevated ICH risks.
- Cumulative odds ratios increased significantly with decreasing temperatures: 1.37 at 10°C, 1.92 at 0°C, 3.13 at -10°C, and 5.76 at -20°C, compared to 20°C.
- The association between low temperature and ICH risk was primarily observed within three hours of exposure.
Conclusions:
- Short-term exposure to low ambient temperatures increases the risk of acute intracerebral hemorrhage (ICH).
- Findings highlight the potential impact of environmental temperature on cerebrovascular events.
