Related Experiment Video
Updated: Mar 26, 2026

Author Spotlight: Unraveling the Molecular Mechanisms in PCO and Fibrosis Following Cataract Surgery
Published on: December 1, 2023
Effect of lanosterol on human cataract nucleus
P Mahesh Shanmugam1, Aditya Barigali, Jayant Kadaskar
1Department of Vitreoretinal Services and Ocular Oncology, Sankara Eye Hospital, Kundalahalli Gate, Bengaluru, Karnataka, India.
Aim:
To study the effect of lanosterol on age-related cataractous human lens nuclei.
Materials And Methods:
Forty age-related cataractous nuclei removed during manual small incision cataract surgery were obtained and randomly immersed in 25 mM lanosterol solution or in control solution and stored at room temperature for 6 days. Pre- and post-immersion photographs were graded by two masked observers and collated for the regression or progression of lens opacity.
Results:
Both lanosterol and control groups showed progression or no change in the lens opacity at the end of 6 days.
Conclusion:
Lanosterol 25 mM solution did not reverse opacification of human age-related cataractous nuclei.
Related Concept Videos
Transducer Mechanism: Nuclear Receptors
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
Regulation of Nuclear Protein Sorting

