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Updated: Mar 26, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

806

[BRONCHOPULMONARY DYSPLASIA--WHAT DO WE KNOW TODAY?]

P Radulova, L Vakrilova, B Slancheva

    Akusherstvo I Ginekologiia
    |February 12, 2016
    PubMed

    Insights

    Extremely premature newborns face higher risks of lung damage and Bronchopulmonary dysplasia (BPD). Lower gestational age and weight correlate with increased BPD frequency, impacting lung development and leading to new treatments.

    Area of Science:

    • Neonatology
    • Pediatric Pulmonology
    • Perinatal Medicine

    Context:

    • Survival rates for extremely premature infants have improved.
    • This improved survival is linked to a higher incidence of neonatal lung injury.
    • Bronchopulmonary dysplasia (BPD) is a significant complication in these vulnerable infants.

    Purpose:

    • To review the current understanding of Bronchopulmonary dysplasia (BPD) in extremely premature newborns.
    • To discuss evolving theories on BPD pathogenesis.
    • To highlight recent advancements in BPD staging and therapeutic approaches.

    Summary:

    • Bronchopulmonary dysplasia (BPD) is a chronic lung disease affecting premature infants, characterized by impaired alveolization and vascularization.
    • The risk and severity of BPD are inversely related to gestational age and birth weight.
    • New insights into BPD's development are driving innovative treatment strategies.

    Impact:

    • Understanding BPD pathogenesis is crucial for developing targeted interventions.
    • Revised staging aids in consistent diagnosis and outcome assessment.
    • Novel therapeutic strategies aim to improve long-term respiratory outcomes for premature infants.

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