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Related Experiment Video

Updated: Mar 26, 2026

A Polyaniline-based Sensor of Nucleic Acids

A Polyaniline-based Sensor of Nucleic Acids

Published on: November 1, 2016

DNA-Based Sensor Particles Enable Measuring Light Intensity in Single Cells.

Gediminas Mikutis¹, Carlos A Mora¹, Michela Puddu¹

¹Institute for Chemical and Bioengineering, ETH Zürich, Vladimir-Prelog-Weg 1, 8093, Zürich, Switzerland.

Advanced Materials (Deerfield Beach, Fla.)

|February 12, 2016

Summary

This summary is machine-generated.

Researchers developed a novel light nanosensor using a "lab on a particle" approach. This DNA-based sensor, encapsulated in silica, measures light intensity and duration in tiny volumes like single cells.

Keywords:

caged oligonucleotides light sensors nanosensor sensor particles single cell analysis

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Area of Science:

Nanotechnology
Biomedical Engineering
Materials Science

Background:

Developing miniaturized sensors for precise biological measurements is crucial.
Existing methods for light measurement in micro-volumes face limitations.

Purpose of the Study:

To design and characterize a novel light nanosensor with "lab on a particle" architecture.
To enable measurement of light intensity and duration in confined biological environments.

Main Methods:

Utilizing DNA encapsulated within silica particles.
Functionalizing DNA with light-sensitive protecting groups.
Implementing a "lab on a particle" design for self-sufficient sensing.

Main Results:

The nanosensor successfully measures light intensity and duration.
Demonstrated capability for sensing in very small volumes, including single cells.
The sensor stores irradiation information for later readout.

Conclusions:

The developed nanosensor offers a new tool for precise light dosimetry in cellular and subcellular environments.
This technology facilitates long-term monitoring of light exposure in biological samples.
The "lab on a particle" approach provides a robust platform for advanced nanosensor development.