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THE CONTENT OF MICROELEMENTS IN BLOOD SERUM AND ERYTHROCYTES IN CHILDREN WITH DIABETES MELLITUS TYPE I DEPENDING ON

N Gluschenko1, Kh Vasylyshyn1, A Roschupkin1

  • 1Sumy State University, Ukraine.

Georgian Medical News
|February 13, 2016
PubMed

Insights

Glycemic control in children with type 1 diabetes impacts trace element levels. Poor control is linked to deficiencies in chromium, cobalt, and nickel, affecting long-term health outcomes.

Area of Science:

  • Pediatric Endocrinology
  • Clinical Chemistry
  • Trace Element Metabolism

Background:

  • Type 1 diabetes mellitus (T1DM) in children requires careful management of glycemic control.
  • Trace elements like chromium, cobalt, and nickel play crucial roles in metabolic processes.
  • The relationship between glycemic control and trace element status in pediatric T1DM is not fully understood.

Purpose of the Study:

  • To investigate serum and erythrocyte levels of chromium, cobalt, and nickel in children with T1DM.
  • To determine the association between these trace element levels and the degree of glycemic control.
  • To explore the influence of T1DM duration on trace element concentrations.

Main Methods:

  • Study included 68 children with T1DM, categorized into four groups based on glycemic control (optimal, suboptimal, high-risk, and healthy controls).
  • Glycemic control was assessed using ISPAD 2000 guidelines.
  • Trace element concentrations were measured using atomic absorption spectrophotometry with a C-115M1 mass-spectrophotometer.

Main Results:

  • Optimal glycemic control was associated with decreased serum chromium and erythrocyte cobalt.
  • Suboptimal control showed chromium and cobalt deficiency, with lower cobalt and nickel but higher erythrocyte chromium.
  • High-risk glycemic control correlated with significant serum deficiencies of cobalt, nickel, and chromium; chromium increased in erythrocytes.

Conclusions:

  • Glycemic control level significantly influences chromium, cobalt, and nickel concentrations in children with T1DM.
  • Duration of T1DM primarily affects serum cobalt and nickel levels.
  • Trace element imbalances, particularly deficiencies, are linked to poor glycemic control and may impact diabetic complication development.

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