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Molecular Epidemiology of Enteric Adenovirus Gastroenteritis in under-Five-Year-Old Children in Iran

Anahita Sanaei Dashti1, Pedram Ghahremani2, Tayebeh Hashempoor3

  • 1Shiraz HIV/AIDS Research Center, Shiraz University of Medical Sciences, Shiraz 7193613311, Iran.

Gastroenterology Research and Practice
|February 17, 2016
PubMed

Insights

Human adenovirus (HAdV)-40 and HAdV-41 are significant causes of acute gastroenteritis in Iranian children. Early detection using PCR aids in managing the illness and preventing unnecessary antibiotic use.

Area of Science:

  • Pediatrics
  • Virology
  • Epidemiology

Background:

  • Acute gastroenteritis is a leading cause of illness and death in young children globally.
  • Human adenovirus (HAdV) types 40 and 41 are common pathogens in pediatric gastroenteritis.

Purpose of the Study:

  • To determine the prevalence of HAdV-40 and HAdV-41 in hospitalized children with gastroenteritis in Iran.
  • To identify the etiological role of these viruses in pediatric acute gastroenteritis.

Main Methods:

  • A cross-sectional epidemiological study involving 2682 fecal specimens from children under 5 years old.
  • Samples collected from five pediatric centers in Iran between February 2012 and February 2013.
  • Polymerase chain reaction (PCR) used to detect HAdV-40 and HAdV-41.

Main Results:

  • HAdV-40 and HAdV-41 were detected in 5.18% (132/2682) of children with diarrhea.
  • Prevalence was significantly higher (58.3%) in infants under 12 months.
  • The male to female ratio was 1.7.

Conclusions:

  • HAdV-40 and HAdV-41 are significant etiological agents of acute gastroenteritis in Iranian children.
  • PCR offers a rapid diagnostic method, potentially leading to better patient outcomes and reduced antibiotic use.

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