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Quantra™ should be considered a tool for two-grade scale mammographic breast density classification.
Ernest U Ekpo1,2, Mark F McEntee1, Mary Rickard1,3
11 Discipline of Medical Radiation Sciences in the Faculty of Health Sciences and the Brain and Mind Research Institute, The University of Sydney, Australia.
The British Journal of Radiology
|February 17, 2016
Summary
Quantra shows high agreement with Breast Imaging Reporting and Data Systems (BI-RADS) for two-grade mammographic breast density (MBD) assessment. However, its ability to reproduce BI-RADS ratings on a four-grade scale is limited.
Area of Science:
- Radiology and Medical Imaging
- Quantitative Breast Imaging Analysis
Background:
- Mammographic breast density (MBD) is a crucial factor in breast cancer risk assessment.
- Standardized assessment of MBD is essential for consistent clinical interpretation and research.
Purpose of the Study:
- To evaluate the agreement between the Quantra™ system and the Breast Imaging Reporting and Data Systems (BI-RADS) for MBD assessment.
- To determine the performance of Quantra in replicating BI-RADS MBD classifications.
Main Methods:
- MBD was assessed using both Quantra and BI-RADS criteria across two study phases.
- Interreader agreement and agreement between Quantra and BI-RADS were calculated using Kappa statistics.
- Receiver-operating characteristics analysis assessed Quantra's accuracy in reproducing BI-RADS ratings.
Main Results:
- Weighted kappa for BI-RADS and Quantra agreement was 0.75 (four-grade) and 0.85 (two-grade) in Phase 1.
- Phase 2 showed similar agreement: 0.79 (four-grade) and 0.84 (two-grade).
- Quantra achieved 93.2% sensitivity and 86.1% specificity for BI-RADS on a two-grade scale in Phase 1.
Conclusions:
- Quantra demonstrates strong agreement with BI-RADS for two-grade MBD classification.
- The Quantra system has limitations in accurately reproducing BI-RADS assessments on a four-grade scale.
- Quantra is best utilized as a tool for two-grade MBD categorization.
