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Biomarkers in Post-stroke Depression
Vinicius Sousa Pietra Pedroso, Milene Alvarenga Rachid, Antonio Lucio Teixeira1
1Department of Psychiatry and Behavioral Sciences, Room BBS 3140, 1941 East Road, Houston, TX 77054, USA. altexr@gmail.com.
Current Neurovascular Research
|February 20, 2016
Summary
Currently, no specific biomarkers reliably diagnose post-stroke depression (PSD). Research suggests potential links to inflammation, oxidative stress, and genetics, aiding future personalized stroke patient care.
Area of Science:
- Neuroscience
- Psychiatry
- Biomarkers
Background:
- Post-stroke depression (PSD) is a common complication impacting patient outcomes.
- Current PSD diagnosis relies solely on clinical assessments, lacking objective measures.
- Identifying biomarkers is crucial for understanding and managing PSD.
Purpose of the Study:
- To systematically review existing literature for biomarkers associated with post-stroke depression (PSD).
- To evaluate the evidence for various biomarkers in relation to PSD development and progression.
Main Methods:
- Systematic literature review across Medline, Lilacs, and PsycInfo databases.
- Analysis of 37 studies investigating biomarkers linked to post-stroke depression.
- Synthesis of evidence for each evaluated biomarker.
Main Results:
- No single biomarker demonstrated consistent evidence for diagnosing PSD.
- Observed alterations in inflammatory balance, oxidative stress, and glutamatergic neurotransmission.
- Potential associations noted with neurotrophic factors and genetic susceptibility.
Conclusions:
- No definitive biomarker currently exists for post-stroke depression diagnosis.
- Emerging research highlights potential roles of inflammation, oxidative stress, and genetics.
- Future biomarker research may enable personalized stroke management and improved PSD understanding.
