Polymeric Based Therapeutic Delivery Systems Prepared Using Electrohydrodynamic Processes

Area of Science:

• Polymer science and engineering
• Pharmaceutical technology
• Biomaterials science

Background:

• Polymeric excipients are crucial in therapeutic dosage systems, offering functions like controlled release and adhesion.
• Synthetic polymers (e.g., PCL, PLGA) and natural polymers (e.g., lactose, gelatin) are widely used.
• Advances in processing technologies like spray drying and microfluidics enable novel material structures.

Purpose of the Study:

• To review key developments in electrohydrodynamic (EHDA) engineering for pharmaceutical and biomaterial applications.
• To discuss the principles, parameters, and variables of EHDA processes.
• To highlight the potential of EHDA in fabricating polymeric excipients.

Main Methods:

• Focus on electrohydrodynamic (EHDA) engineering techniques.
• Review of synthetic and naturally occurring polymers as pharmaceutical excipients.
• Discussion of EHDA process principles, material, and engineering parameters.

Main Results:

• EHDA technologies can fabricate diverse structures (particles, fibers, patterns) across various scales.
• EHDA processes operate at ambient conditions and are viable for large-scale production.
• EHDA shows promise for established applications (films, dressings) and emerging fields (nanomedicines, tissue engineering).

Conclusions:

• EHDA engineering presents a robust platform for developing advanced polymeric excipients.
• These technologies offer versatile fabrication capabilities for pharmaceutical and biomaterial applications.
• EHDA is a promising approach for both current and future therapeutic system development.