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Updated: Mar 25, 2026
A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
Published on: November 30, 2021
[Diagnostic value of prealbumin for severe necrotizing enterocolitis]
Yang Yang1, Jing-Jing Pan, Xiao-Yu Zhou
1Department of Neonatolgy, Nanjing Children′s Hospital of Nanjing Medical University, Nanjing 210008, China. yy860508@163.com.
Objective:
To study the clinical features of severe neonatal necrotizing enterocolitis (NEC), and to investigate the diagnostic value of prealbumin (PA) in neonates with severe NEC.
Methods:
The clinical data and results of routine blood test and blood biochemical test of 40 neonates with NEC (29 neonates with NEC II and 11 with NEC III) were analyzed. The multivariate logistic regression analysis and receiver operating characteristic (ROC) curve were applied to investigate the value of PA in the diagnosis of severe NEC.
Results:
The multivariate logistic regression analysis showed that PA was an important index for the diagnosis of severe NEC (≥IIB). The ROC analysis showed that in the diagnosis of severe NEC (≥IIB), PA had high sensitivity (0.870) and specificity (0.647).
Conclusions:
PA has a good value in the diagnosis of severe NEC.
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