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Updated: Mar 25, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

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The role of kinetic context in apparent biased agonism at GPCRs

Carmen Klein Herenbrink1, David A Sykes2, Prashant Donthamsetti3,4

  • 1Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.

Nature Communications
|February 25, 2016
PubMed

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