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Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
Published on: June 13, 2018
Fungal skin and soft tissue infections
Sarah Guégan1, Fanny Lanternier, Claire Rouzaud
1aAssistance Publique-Hôpitaux de Paris, Service de Dermatologie, Hôpital TenonbUniversité Pierre et Marie Curie-Paris VIcINSERM U938, Saint Antoine Research CenterdInstitut Pasteur, Unité de Mycologie Moléculaire, Centre National de Référence Mycoses Invasives et AntifongiqueseCNRS URA3012fAssistance Publique-Hôpitaux de Paris, Centre d'Infectiologie Necker Pasteur, Hôpital Necker-Enfants maladesgUniversité René Descartes-ParishAssistance Publique-Hôpitaux de Paris, Service de Dermatologie, Hôpital Cochin, Paris, France.
Purpose Of Review:
Cutaneous and subcutaneous mycoses are a source of significant morbidity both in immunocompetent and immunocompromised patients. We here review the latest findings in terms of genetic predisposition, epidemiology, clinical manifestations, and therapeutic strategies in these diseases.
Recent Findings:
A growing number of fungal skin and soft tissue infections are reported worldwide. In immunocompromised patients, these infections are often associated with disseminated disease. Skin and soft tissue biopsies usually allow mycological identification. Although tissue culture remains the gold standard, molecular biology is increasingly used and sometimes mandatory for accurate diagnosis. Advances in therapeutics have improved outcome and lowered dissemination risk in patients.
Summary:
Cutaneous and subcutaneous mycoses are an evolving field. Clinicians all over the world should be aware of the common manifestations of these diseases - infectious diseases - as they are increasingly reported and may lead to or be associated with dissemination.
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