Related Experiment Video

Updated: Mar 25, 2026

Mechanical Control of Relaxation Using Intact Cardiac Trabeculae
07:51

Mechanical Control of Relaxation Using Intact Cardiac Trabeculae

Published on: February 17, 2023

1.6K

The Muscle-Bound Heart

Marwan M Refaat1, Akl C Fahed2, Sylvana Hassanieh3

  • 1Cardiac Electrophysiology, Cardiology, Department of Internal Medicine, American University of Beirut Faculty of Medicine and Medical Center, PO Box 11-0236, Riad El-Solh, Beirut 1107 2020, Lebanon; Department of Biochemistry and Molecular Genetics, American University of Beirut Faculty of Medicine and Medical Center, PO Box 11-0236, Riad El-Solh, Beirut 1107 2020, Lebanon; Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon; Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.

Cardiac Electrophysiology Clinics
|February 28, 2016
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) is a genetic heart condition with varied symptoms and causes, posing risks, especially for young adults. Ongoing research aims to better understand HCM

Area of Science:

  • Cardiology
  • Genetics
  • Personalized Medicine

Background:

  • Hypertrophic cardiomyopathy (HCM) is a prevalent genetic cardiac disorder.
  • It presents with diverse clinical manifestations and genetic underpinnings.
  • HCM poses significant risks, particularly to young adults.

Observation:

  • Extensive research is underway to correlate patient phenotypes with genotypes.
  • Understanding these links is crucial for improved disease management and complication control.
  • The complete pathogenic mechanisms of HCM remain incompletely understood.

Findings:

  • Current therapeutic strategies for HCM are not definitive due to incomplete mechanistic understanding.
  • Categorizing patients based on genotype-phenotype links is an active area of investigation.
  • Further research is essential for a comprehensive understanding of HCM.

Implications:

  • Advancing research into HCM mechanisms and genetics can lead to more targeted therapies.
  • Improved patient stratification may enhance clinical outcomes and disease prognosis.
  • A complete picture of HCM will facilitate the development of definitive treatment protocols.

Keywords:
GenotypeHypertrophic cardiomyopathyLeft ventricleMuscle-bound heartPhenotype

More Related Videos

Magnetic Adjustment of Afterload in Engineered Heart Tissues09:40

Magnetic Adjustment of Afterload in Engineered Heart Tissues

Published on: May 5, 2020

6.3K
Semi-automated Optical Heartbeat Analysis of Small Hearts12:10

Semi-automated Optical Heartbeat Analysis of Small Hearts

Published on: September 16, 2009

12.9K

Related Concept Videos

Structure of Cardiac Muscles01:13

Structure of Cardiac Muscles

Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
18.9K
Anatomy of the Heart01:27

Anatomy of the Heart

The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
122.4K
Anatomy of the Heart01:20

Anatomy of the Heart

The heart is a hollow, muscular organ approximately the size of a fist, consisting of four chambers. It is enclosed in the pericardium, a fibrous sac with two layers: the visceral and parietal pericardium, separated by a fluid-filled space containing serous fluid to reduce friction.
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
4.6K
Location and Orientation of the Heart01:13

Location and Orientation of the Heart

The human heart, despite its modest size and weight, is an organ of remarkable strength and endurance. Roughly the size of a fist, the heart weighs between 250 and 350 grams and is nestled within the mediastinum, the medial cavity of the thorax. It extends obliquely for about 12 to 14 cm, resting on the superior surface of the diaphragm. The heart is positioned anterior to the vertebral column and posterior to the sternum, with two-thirds of its mass lying to the left of the midsternal line.
13.3K
Specialized Characteristics of Cardiac Muscles01:27

Specialized Characteristics of Cardiac Muscles

The primary role of cardiac muscles is to propel blood throughout the cardiovascular system. The cardiac muscle cells, or cardiomyocytes, exhibit specialized characteristics that allow them to perform this function.
Cardiac muscle cells are smaller than skeletal muscles, averaging 10–20 mm in diameter and 50–100 mm in length. However, they have large energy demands for continuous contraction and relaxation. This energy is almost exclusively derived from aerobic metabolism of energy...
4.7K
Heart Valves01:16

Heart Valves

The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
13.5K