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Updated: Mar 25, 2026

Collection of Serum- and Feeder-free Mouse Embryonic Stem Cell-conditioned Medium for a Cell-free Approach
Published on: January 8, 2017
iPSCs-based anti-aging therapies: Recent discoveries and future challenges
Helios Pareja-Galeano1, Fabián Sanchis-Gomar2, Laura M Pérez3
1European University of Madrid, Spain; Research Institute of Hospital 12 de Octubre ("i+12"), Madrid, Spain.
Abstract:
The main biological hallmarks of the aging process include stem cell exhaustion and cellular senescence. Consequently, research efforts to treat age-related diseases as well as anti-aging therapies in general have recently focused on potential 'reprogramming' regenerative therapies. These new approaches are based on induced pluripotent stem cells (iPSCs), including potential in vivo reprogramming for tissue repair. Another possibility is targeting pathways of cellular senescence, e.g., through modulation of p16INK4a signaling and especially inhibition of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). Here, we reviewed and discussed these recent developments together with their possible usefulness for future treatments against sarcopenia, a major age-related condition.
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