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Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

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Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid...
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Necrosis01:16

Necrosis

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Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
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Related Experiment Video

Updated: Mar 25, 2026

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model
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Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model

Published on: July 28, 2023

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Current research in necrotizing enterocolitis.

Simon Eaton1, Clare M Rees1, Nigel J Hall2

  • 1UCL Institute of Child Health and Great Ormond Street Hospital for Children, London, UK.

Early Human Development
|March 1, 2016
PubMed
Summary
This summary is machine-generated.

Necrotizing enterocolitis (NEC) pathogenesis remains unclear, but recent advances offer hope for improved prevention and treatment strategies for this devastating infant disease.

Keywords:
TLR4inflammationintestinal microbiotanecrotizing enterocolitispremature infantssurgery

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Area of Science:

  • Neonatal Medicine
  • Gastroenterology
  • Infant Health

Background:

  • Necrotizing enterocolitis (NEC) is a severe intestinal disease affecting premature infants.
  • Despite extensive research, the exact causes, prevention, and treatment of NEC are not fully understood.

Purpose of the Study:

  • To highlight recent advances in understanding NEC pathogenesis.
  • To convey hope for future improvements in NEC outcomes based on new research.

Main Methods:

  • Review of recent scientific literature.
  • Focus on advances in microbiology, molecular biology, and cell biology related to infant intestines.

Main Results:

  • Significant progress has been made in understanding the intestinal biology of infants with NEC.
  • New insights into NEC pathogenesis are emerging from interdisciplinary research.

Conclusions:

  • Recent scientific breakthroughs provide a foundation for translating research into improved NEC prevention and treatment.
  • Further research holds promise for better outcomes for infants affected by necrotizing enterocolitis.