[Epigenetics and Life-style diseases]
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Updated: Mar 25, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
Published on: May 6, 2022
Hironori Waki1, Toshimasa Yamauchi2, Takashi Kadowaki2
1Department of Diabetes and Metabolic Diseases, Functional Regulation of Adipocytes,Graduate School of Medicine, the University of Tokyo, Japan.
Abstract:
Genomic DNA in eukaryotes forms a highly-organized structure called chromatin. Epigenetic regulation of genes involves DNA methylation and modifications of the histone tails such as acetylation and methylation, which lead to a given phenotype without a change in nucleotide sequence. Both genetic and environmental factors play important roles in the development of life-style diseases. Epigenetic regulation is implicated to contribute to the interplay between the environmental and genetic factors. Advance in DNA sequencing technologies provides novel insights into transcriptional and epigenetic regulation of the genes and mechanisms by which genomic polymorphism causes diseases. We will overview recent progress in the epigenetic studies on life-style diseases.
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