[Peritoneosorption in the treatment of diffuse peritonitis in children]

Area of Science:

• Surgical critical care
• Peritoneal disease management
• Experimental medicine

Background:

• Diffuse peritonitis presents significant challenges in pediatric critical care.
• Current treatment protocols for terminal and toxic peritonitis phases require optimization.
• Abdominal cavity pH modulation is an emerging therapeutic strategy.

Purpose of the Study:

• To evaluate the efficacy of trisamine solution for abdominal pH correction in diffuse peritonitis.
• To assess the outcomes of peritoneosorption using hemodes in pediatric peritonitis patients.
• To compare closed versus open abdominal management in conjunction with these treatments.

Main Methods:

• Experimental study involving 225 inbred albino rats.
• Clinical experience with 143 children suffering from terminal and toxic diffuse peritonitis.
• Application of trisamine solution for pH adjustment and hemodes for peritoneosorption.

Main Results:

• Successful correction of abdominal cavity pH was achieved using trisamine solution.
• Peritoneosorption with hemodes demonstrated effectiveness in both one-stage and prolonged treatments.
• Outcomes were analyzed under both closed and open abdominal cavity management strategies.

Conclusions:

• Trisamine solution and hemodes peritoneosorption represent a viable approach for managing severe diffuse peritonitis.
• The study provides valuable data for refining treatment protocols in pediatric surgical patients.
• Further research is warranted to fully elucidate the long-term benefits and optimal application of these methods.