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Updated: Mar 24, 2026
Optical Imaging of Isolated Murine Ventricular Myocytes
Published on: January 17, 2020
Multicenter study of optical low-coherence interferometry and partial-coherence interferometry optical biometers with
Kenneth J Hoffer1, H John Shammas1, Giacomo Savini1
1From Stein Eye Institute (Hoffer), University of California, Los Angeles; St. Mary's Eye Center (Hoffer), Santa Monica, California; Keck School of Medicine (Shammas), Los Angeles, and; Shammas Eye Medical Center (Shammas), Lynwood, California, USA; G.B. Bietti Foundation IRCCS (Savini), Rome, Italy; School of Ophthalmology and Eye Hospital (Huang), Wenzhou Medical University, Wenzhou, China.
Purpose:
To evaluate the agreement between the measurements provided by a new optical biometer, the Aladdin, based on optical low-coherence interferometry (OLCI), and those provided by the most commonly used optical biometer (IOLMaster 500), based on partial-coherence interferometry (PCI).
Setting:
Multicenter clinical trial.
Design:
Prospective evaluation of diagnostic test.
Methods:
In this study, 2 samples of adult patients were enrolled, 1 in the United States and the other in China. The U.S. group included a sample of consecutive patients scheduled for cataract surgery. The China group included a sample of healthy subjects with no cataracts. In both cases, only 1 eye of each patient was analyzed. Axial length (AL), corneal power (in diopters [D]) (K), anterior chamber depth (ACD) (corneal epithelium to lens), and corneal astigmatism were measured. All values were analyzed using a paired t test, the Pearson product-moment correlation coefficient (r), and Bland-Altman plots.
Results:
In the U.S. and China groups, the OLCI mean AL values did not show a statistically significant difference from PCI values and showed excellent agreement and correlation. On the contrary, OLCI measured a lower mean K (-0.14 D) and a deeper ACD measurements (U.S. +0.16 mm and China +0.05 mm). These differences were statistically significant (P < .0001). Vector analysis did not show a statistically significant difference in astigmatism measurements.
Conclusions:
Agreement between OLCI and PCI was good. However, the small but statistically significant differences in K and ACD measurements make constant optimization necessary when calculating the intraocular lens power using theoretical formulas.
Financial Disclosure:
Dr. Hoffer licenses the registered trademark name Hoffer to Carl Zeiss-Meditec (PCI), Haag-Streit (Lenstar), Movu (Argos), Oculus (Pentacam, AXL), Nidek (AL-Scan), Tomey (OA-2000), Topcon EU Visia Imaging (Aladdin), Ziemer (Galilei G6), and all A-scan biometer manufacturers. Dr. Shammas licenses his formulas to Carl Zeiss-Meditec (PCI), Haag-Streit (Lenstar), Nidek (AL-Scan), and Topcon EU (Visia Imaging) (Aladdin). None of the other authors has a financial or proprietary interest in any material or method mentioned.
