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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Author Spotlight: Unlocking Insights into the Immune Cell Landscape of Tumors
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Imaging Biomarkers in Immunotherapy.

Rosalyn A Juergens1, Katherine A Zukotynski2, Amit Singnurkar2

  • 1Department of Oncology, McMaster University, Hamilton, ON, Canada.

Biomarkers in Cancer
|March 8, 2016
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Molecular imaging offers a noninvasive way to monitor cancer immunotherapies. This approach helps clinicians select patients and track treatment response, addressing a key challenge in cancer care.

Keywords:
biomarkerimmunotherapymolecular imaging

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Area of Science:

  • Oncology
  • Immunology
  • Radiology

Background:

  • Immune-based therapies, including immune checkpoint inhibitors, have transformed cancer treatment.
  • A significant challenge remains the lack of reliable biomarkers for patient selection and response monitoring.

Purpose of the Study:

  • To review the mechanisms of immunotherapies.
  • To explore molecular imaging as a tool for monitoring cancer immunotherapy response.
  • To summarize current research on molecular imaging of the immune system in cancer.

Main Methods:

  • Literature review of preclinical and clinical studies.
  • Analysis of immunotherapy mechanisms.
  • Evaluation of molecular imaging techniques for immune monitoring.

Main Results:

  • Molecular imaging provides a noninvasive method for evaluating tumors.
  • Current imaging strategies show promise for monitoring immunotherapy.
  • Research highlights the potential of molecular imaging in cancer immunotherapy.

Conclusions:

  • Molecular imaging is a promising tool for overcoming biomarker limitations in cancer immunotherapy.
  • Further research is needed to fully integrate molecular imaging into clinical practice for immune-based cancer treatments.