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Encapsulation of cannabinoid drugs in nanostructured lipid carriers
Elisabetta Esposito1, Markus Drechsler2, Rita Cortesi1
1Department of Life Sciences and Biotechnology, University of Ferrara, I-44121 Ferrara, Italy.
Abstract:
This study describes the development and optimization of a method to encapsulate the potent and expensive cannabinoids drugs in nanostructured lipid carriers; namely, URB597, AM251 and rimonabant have been considered. NLC production by melt and ultrasonication protocol has been specifically designed to optimize nanoparticle recovery and drug encapsulation efficiency. Special care has been devoted to the modality of oil and water phase emulsification and the entire production has been studied and discussed. NLC recovery, morphology, dimensional distribution and encapsulation efficiency are presented.
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