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Specific Targeting of Akt Kinase Isoforms: Taking the Precise Path for Prevention and Treatment of Cancer

Nand Kishor Roy, Devivasha Bordoloi, Javadi Monisha

  • 1Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Room # 005, O-Block, Guwahati, Assam-781039, India.

Current Drug Targets
|March 9, 2016
PubMed

Insights

Akt kinase isoforms orchestrate cell functions but also drive cancer development and resistance. Understanding their distinct roles offers new therapeutic targets for cancer prevention and treatment.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Akt kinase, a serine/threonine kinase, has three isoforms with distinct expression and functions.
  • These isoforms play crucial roles in cellular processes, with overlapping, specific, and sometimes opposing actions.
  • Alterations in Akt isoforms are implicated in cancer development and resistance to chemotherapy and radiotherapy.

Purpose of the Study:

  • To comprehensively review the divergent roles of Akt isoforms in various cancers.
  • To highlight the potential of Akt isoforms as prognostic biomarkers.
  • To explore the prospects of targeting Akt isoforms for cancer prevention and treatment.

Main Methods:

  • Literature review of studies on Akt isoforms in cancer.
  • Analysis of isoform-specific involvement in different cancer types.
  • Synthesis of current knowledge on Akt alterations and their clinical implications.

Main Results:

  • Akt isoforms exhibit unique functions and specific involvement in different cancers.
  • Aberrant Akt signaling contributes to tumorigenesis and treatment resistance.
  • Akt isoforms show promise as reliable prognostic biomarkers.

Conclusions:

  • Isoform-specific understanding of Akt kinase is crucial for cancer research.
  • Targeting specific Akt isoforms presents a promising strategy for novel cancer therapies.
  • Further investigation into Akt isoform functions can advance cancer prevention and treatment modalities.
Keywords:
Akt1Akt2Akt3biomarkers.cancertargets

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