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BONE MINERAL DENSITY IN CHILDREN WITH IDIOPATHIC HYPERCALCIURIA
Developmental Period Medicine
|March 10, 2016
Summary
Idiopathic hypercalciuria in children is linked to lower bone mineral density (BMD) in the lumbar spine, often associated with vitamin D3 deficiency. This deficiency may contribute to reduced BMD and an increased risk of kidney stones.
Area of Science:
- Pediatric Endocrinology
- Nephrology
- Bone Metabolism
Background:
- Idiopathic hypercalciuria (IH) is a common condition in children.
- Potential impact of IH on bone health is not fully understood.
- Evaluating bone mineral density (BMD) in children with IH is crucial.
Purpose of the Study:
- To assess lumbar spine BMD in children diagnosed with idiopathic hypercalciuria.
- To investigate the relationship between BMD, vitamin D status, and other biochemical markers in these children.
Main Methods:
- A cohort of 31 children (ages 5-17) with IH was studied.
- Lumbar spine BMD (L1-L4) was measured using Z-scores.
- Serum levels of 25-hydroxyvitamin D3 (250HD3), calcium, phosphorus, ALP, and iPTH were analyzed.
- 24-hour urinary calcium, phosphorus, and sodium excretion were evaluated.
Main Results:
- 25.8% of children exhibited reduced lumbar spine BMD (Z-score <-1).
- Vitamin D3 deficiency (250HD3 < 20 ng/mL) was prevalent in 71% of participants.
- A positive correlation was observed between lumbar spine BMD Z-score and serum 250HD3 levels.
- Nephrolithiasis was present in 50% of children with reduced BMD.
Conclusions:
- Reduced lumbar spine BMD in children with IH appears to be associated with vitamin D3 deficiency.
- Vitamin D3 deficiency may play a significant role in the bone health complications of IH.
- Further research into vitamin D supplementation for children with IH and reduced BMD is warranted.
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