Related Experiment Video
Updated: Mar 24, 2026
Skeletal Muscle Gender Dimorphism from Proteomics
Published on: December 14, 2011
Gender Differences in C-Reactive Protein and Muscle Strengthening Activity
Michael R Richardson1, Tammie M Johnson, Peter T Katzmarzyk
1Dept of Clinical and Applied Movement Sciences, University of North Florida, Jacksonville, FL.
Background:
Few studies have examined the gender differences between C-reactive protein (CRP) and muscle strengthening activity (MSA).
Methods:
The sample (n = 7533) included U.S. adult (≥20 years of age).participants in the 1999-2004 National Health and Nutrition Examination Survey (NHANES). Created categories of MSA participation included no MSA (referent group), some MSA (≥1 to <2 days/week), and meeting the 2008 Department of Health and Human Services (DHHS) recommendation (≥2 days/week). The dependent variable was elevated CRP (>3 to 10 mg/L).
Results:
Analysis revealed significantly lower odds of having elevated CRP for women reporting some MSA (OR 0.64; 95% CI 0.44-0.93, P = .0191). Significantly lower odds of men having elevated CRP was observed in those reporting MSA volumes meeting the DHHS recommendation (OR 0.72; 95% CI 0.59-0.88, P = .0019). Following adjustment for waist circumference (WC) these odds remained significant in men but not women.
Conclusions:
These results suggest that WC may mediate the associations between MSA and CRP and this relationship may be stronger in women.
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