Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Reflex Activity01:08

Reflex Activity

4.4K
A reflex activity is an automatic, involuntary response to specific stimuli. It is a part of our survival mechanism, designed to protect us from potential harm. For example, when a bright light suddenly shines into our eyes, we instinctively close them or look away. This is a simple reflex activity orchestrated by the nervous system without conscious thought or effort.
A reflex exam is a diagnostic procedure performed by a healthcare professional to evaluate the functionality of a patient's...
4.4K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

2.0K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
2.0K
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

646
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
646
Inflammation01:38

Inflammation

64.0K
Overview
64.0K
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

593
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
593

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Austin Sumner 1938-2025.

Neurology·2026
Same author

Polyneuropathy in kidney transplant recipients: a cross-sectional study in Groningen, the Netherlands.

BMJ open·2026
Same author

Incidence and prevalence of small fibre neuropathy in the Netherlands: a multiple system estimation study.

Journal of neurology, neurosurgery, and psychiatry·2026
Same author

Measurement properties of the Inflammatory Rasch-built Overall Disability Scale (I-RODS) in patients with Guillain-Barré syndrome.

Journal of neurology·2026
Same author

Dynamics of Nerve Conduction Studies in Patients With Guillain-Barré Syndrome.

Muscle & nerve·2026
Same author

Epimutation analysis reveals involvement of SLIT2/ROBO signaling pathway in painful diabetic neuropathy.

Human genomics·2026
Same journal

De Novo MFN2 p.Arg95Met in Severe Charcot-Marie-Tooth Disease Type 2A.

Journal of the peripheral nervous system : JPNS·2026
Same journal

Autonomic Nervous System Phenotyping Across Chronic Demyelinating Peripheral Neuropathies: A Comparative Study.

Journal of the peripheral nervous system : JPNS·2026
Same journal

Circulating Inflammation-Related Proteins Linked to Corneal Neuroimmune Measures, Neuropathy Deficits, and Symptoms in Type 2 Diabetes.

Journal of the peripheral nervous system : JPNS·2026
Same journal

A Quantitative Assessment of Upper Limb Motor Function Across Disease Stages in Hereditary Transthyretin Amyloidosis.

Journal of the peripheral nervous system : JPNS·2026
Same journal

COQ7-Related Neuropathy: Two New Cases and Review of the Literature.

Journal of the peripheral nervous system : JPNS·2026
Same journal

Health Equality and Socioeconomic Impact of Hereditary Sensory Neuropathy Type 1 (HSN1) in the UK.

Journal of the peripheral nervous system : JPNS·2026
See all related articles

Related Experiment Video

Updated: Mar 24, 2026

Author Spotlight: Using the MouseWalker to Quantify Locomotor Dysfunction in a Mouse Model of Spinal Cord Injury
07:28

Author Spotlight: Using the MouseWalker to Quantify Locomotor Dysfunction in a Mouse Model of Spinal Cord Injury

Published on: March 24, 2023

4.4K

Does ability to walk reflect general functionality in inflammatory neuropathies?

Thomas H P Draak1, Kenneth C Gorson2, Els K Vanhoutte3

  • 1Department of Neurology, University Medical Centre Maastricht, Maastricht, The Netherlands.

Journal of the Peripheral Nervous System : JPNS
|March 13, 2016
PubMed
Summary
This summary is machine-generated.

Walking ability is a recovery benchmark for Guillain-Barré syndrome (GBS) and CIDP patients, but doesn't fully reflect overall function. The Inflammatory-Rasch-built-Overall-Disability-Scale (I-RODS©) offers a more comprehensive assessment.

Keywords:
inflammatory neuropathiesoutcome research

More Related Videos

Automated Gait Analysis in Mice with Chronic Constriction Injury
06:49

Automated Gait Analysis in Mice with Chronic Constriction Injury

Published on: October 17, 2017

10.9K
Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
14:55

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

Published on: April 18, 2011

14.3K

Related Experiment Videos

Last Updated: Mar 24, 2026

Author Spotlight: Using the MouseWalker to Quantify Locomotor Dysfunction in a Mouse Model of Spinal Cord Injury
07:28

Author Spotlight: Using the MouseWalker to Quantify Locomotor Dysfunction in a Mouse Model of Spinal Cord Injury

Published on: March 24, 2023

4.4K
Automated Gait Analysis in Mice with Chronic Constriction Injury
06:49

Automated Gait Analysis in Mice with Chronic Constriction Injury

Published on: October 17, 2017

10.9K
Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
14:55

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

Published on: April 18, 2011

14.3K

Area of Science:

  • Neurology
  • Clinical Recovery Assessment
  • Patient-Reported Outcomes

Background:

  • Walking ability is a key recovery indicator for Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).
  • The extent to which independent walking reflects overall functional recovery remains undetermined in these neuropathies.

Purpose of the Study:

  • To investigate if independent walking ability correlates with comprehensive functional improvement in GBS, CIDP, and monoclonal gammopathy of undetermined significance-related polyneuropathy (MGUSP) patients.
  • To evaluate the utility of the Inflammatory-Rasch-built-Overall-Disability-Scale (I-RODS©) in capturing broader functional deficits.

Main Methods:

  • Serial assessment of 137 newly diagnosed or relapsing GBS, CIDP, and MGUSP patients over one year.
  • Utilized predefined Functional-Acceptable-Clinical-Thresholds (FACTs) at the 50th, 75th, and 90th percentiles of the I-RODS©.
  • Determined the proportion of patients with independent walking ability achieving these I-RODS© thresholds.

Main Results:

  • A significant majority (85%) of ambulatory patients reached the 50th percentile I-RODS© threshold.
  • Fewer patients achieved higher thresholds: 39% reached the 75th, and only 12% reached the 90th percentile.
  • Findings were consistent across different neuropathy types.

Conclusions:

  • Independent walking indicates improvement but does not encompass the full spectrum of functional limitations experienced by patients.
  • The I-RODS© provides a more holistic measure of functional recovery, capturing daily and social deficits beyond mobility.
  • Relying solely on walking ability may underestimate residual functional impairments in GBS, CIDP, and MGUSP.