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Super-resolution Fluorescence Microscopy

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Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...

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Updated: Mar 24, 2026

Lensless Fluorescent Microscopy on a Chip

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Published on: August 17, 2011

Single-pixel imaging using compressed sensing and wavelength-dependent scattering.

Jaewook Shin, Bryan T Bosworth, Mark A Foster

|March 15, 2016

Summary

This summary is machine-generated.

This study presents a novel two-dimensional imaging technique using a fiber optic probe and compressed sensing. The method enables scan-free, fiber-based imaging suitable for micro-endoscopy applications.

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Last Updated: Mar 24, 2026

Lensless Fluorescent Microscopy on a Chip

Lensless Fluorescent Microscopy on a Chip

Published on: August 17, 2011

Single Molecule Fluorescence Microscopy on Planar Supported Bilayers

Single Molecule Fluorescence Microscopy on Planar Supported Bilayers

Published on: October 31, 2015

Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle

Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle

Published on: January 3, 2016

Area of Science:

Optics and Photonics
Biomedical Imaging
Materials Science

Background:

Conventional endoscopic imaging often requires bulky equipment and mechanical scanning mechanisms.
Developing compact, flexible, and high-resolution imaging probes is crucial for minimally invasive procedures.
Speckle patterns generated by light interacting with scattering media offer potential for imaging applications.

Purpose of the Study:

To demonstrate a novel two-dimensional imaging method using a single-mode fiber with a scattering tip.
To develop a scan-free imaging system applicable to micro-endoscopy.
To utilize compressed sensing for image reconstruction from limited data.

Main Methods:

Illumination of objects using deterministic speckle patterns generated by a TiO2-coated fiber tip.
Characterization of wavelength-dependent speckle patterns and total light collection.
Image reconstruction via compressed sensing acquisition using a single photodetector.

Main Results:

Successful two-dimensional imaging demonstrated using the developed fiber-optic probe.
The imaging system is mechanically scan-free and robust to fiber bending.
Optimized TiO2 coating thickness ensures wavelength-sensitive yet repeatable speckle patterns.

Conclusions:

The proposed technique offers a promising approach for compact, flexible, and scan-free micro-endoscopic imaging.
The combination of scattering fiber illumination and compressed sensing enables efficient image reconstruction.
This technology has potential applications in various fields requiring in-situ imaging within confined spaces.