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Penis Allotransplantation in Beagle Dog
Yongbin Zhao1, Weilie Hu1, Lichao Zhang1
1Department of Urology, The General Hospital of Guangzhou Military Command, No. 111, Liuhua Road, Guangzhou, Guangdong 510010, China.
Biomed Research International
|March 16, 2016
Summary
Penis allotransplantation in Beagles demonstrated successful survival and restoration of urination. This research establishes the feasibility of penile allotransplantation, offering potential for human applications.
Area of Science:
- Urology
- Transplantation Surgery
- Veterinary Medicine
Background:
- Penile transplantation is a complex procedure with limited established models.
- Understanding the viability and functional recovery after allogeneic penile transplantation is crucial.
Purpose of the Study:
- To establish a canine model for allogeneic penile transplantation.
- To evaluate the recovery of blood supply and histological changes in transplanted penises.
- To assess the functional outcomes, including urination, after penile allotransplantation.
Main Methods:
- An allogeneic penile transplantation model was created in 20 adult Beagles (10 pairs).
- Post-operative monitoring included macroscopic observation, pathological examination of resected tissues, and functional assessments.
- Urinary function, stream, and patency were evaluated, along with cystourethrography on Day 10.
Main Results:
- Transplanted penises survived the allogeneic transplantation procedure in Beagles.
- The dogs regained the ability to urinate following the transplantation.
- Histopathological examination confirmed tissue viability and architectural changes.
Conclusions:
- Allogeneic penile transplantation is feasible in a Beagle model.
- The study demonstrates successful restoration of urinary function post-transplantation.
- This research provides a foundation for future human penile transplantation procedures.
