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A double-blind comparative study: amineptine (Survector 100) versus imipramine.

N Mendis1, D R Hanwella, C Weerasinghe

  • 1Department of Psychiatry, University of Colombo, Sri Lanka.

Clinical Neuropharmacology
|January 1, 1989
PubMed
Summary

Amineptine and imipramine effectively treat depression symptoms over two months. Amineptine showed fewer anticholinergic side effects, making both antidepressant options suitable for patients.

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Area of Science:

  • Psychiatry
  • Clinical Pharmacology

Background:

  • Depressive illness is a significant mental health condition requiring effective treatment.
  • Amineptine and imipramine are established antidepressant medications.

Purpose of the Study:

  • To compare the efficacy and tolerability of amineptine versus imipramine in treating depressive illness.
  • To evaluate antidepressant effects using standardized rating scales.

Main Methods:

  • A double-blind study involving 33 patients diagnosed with depressive illness.
  • Patients received either imipramine (50-100 mg/day) or amineptine (100-200 mg/day) for 2 months.
  • Symptom severity was assessed using Hamilton Depression Rating Scale, Montgomery-Asberg Depression Rating Scale, and Clinical Global Impression Scale.

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Main Results:

  • Both amineptine and imipramine groups showed consistent improvement in depression symptoms.
  • Amineptine was associated with fewer anticholinergic side effects compared to imipramine.
  • Both treatments were well-tolerated by the study participants.

Conclusions:

  • Amineptine demonstrates comparable antidepressant efficacy to imipramine.
  • Amineptine offers a favorable side effect profile, particularly regarding anticholinergic effects.
  • Both amineptine and imipramine are suitable therapeutic options for managing depressive illness.