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Nanotechnology and Pediatric Cancer: Prevention, Diagnosis and Treatment
H Zare-Zardini1, A Amiri2, M Shanbedi3
1Department of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, Iran; Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
Abstract:
Despite development of new approaches for the treatment of cancer disease, it is the second cause of mortality in world. Annually, 30000 persons die in Iran due to cancer diseases. Eighty percent of cancer patients are children which about 50% children lead to death. Given the high rate of cancer-related death, the new approaches for prevention, control, early diagnosis, and treatment of this disease seem necessary. Investigation of new strategies is the major challenge for scientists at recent century. Nanotechnology as a new scientific field with novel and small compounds utilized different fields over the past ten years especially in medicine. This science has come to the forefront in the areas of medical diagnostics, imaging, and therapeutic scheduls. Therefore, it has the potential applications for cancer detection and therapy. This review will discuss the therapeutic applications of different nano-materials in diagnosis, imaging, and delivery of therapeutic agents for the treatment of cancer with a major focus on their applications for the treatment of cancer and cancer- related diseases in children. The advancements in established nanoparticle technologies such as liposomes, polymer micelles, and functionalization regarding tumor targeting and controlled release strategies as well as drug delivery were discussed. It will also review the blood toxicity of used nanostructures.
Insights
Nanotechnology offers promising therapeutic applications for cancer, particularly in children. This review explores nano-materials for cancer diagnosis, imaging, and drug delivery, focusing on effectiveness and safety.
Area of Science:
- Oncology
- Nanomedicine
- Pediatric Cancer Research
Background:
- Cancer remains a leading cause of mortality globally and in Iran, with a high death rate among children.
- Existing cancer treatments necessitate the development of novel strategies for prevention, diagnosis, and therapy.
- Nanotechnology presents innovative solutions in medicine, including diagnostics, imaging, and therapeutic applications.
Purpose of the Study:
- To review the therapeutic applications of various nano-materials in cancer diagnosis, imaging, and drug delivery.
- To focus on the specific applications of nanotechnology for treating cancer and related diseases in children.
- To discuss advancements in nanoparticle technologies for targeted drug delivery and controlled release, and to review potential blood toxicity.
Main Methods:
- Literature review of therapeutic applications of nano-materials in cancer treatment.
- Focus on established nanoparticle technologies like liposomes and polymer micelles.
- Discussion of functionalization strategies for tumor targeting and controlled release.
Main Results:
- Nanoparticles show potential in cancer detection, imaging, and targeted drug delivery.
- Advancements include enhanced tumor targeting and controlled release mechanisms.
- Potential blood toxicity of nanostructures requires careful consideration.
Conclusions:
- Nanotechnology holds significant promise for improving cancer diagnosis and treatment, especially in pediatric oncology.
- Further research into targeted delivery and safety profiles of nano-materials is crucial.
- Nanomedicine offers a pathway to more effective and potentially less toxic cancer therapies.
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