Related Experiment Video
Updated: Mar 24, 2026

05:27
An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions
Published on: June 30, 2021
5.2K
Talking about cross-talk: the immune system and the microbiome
David Zeevi1,2, Tal Korem1,2, Eran Segal3,4
1Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, 7610001, Israel.
Genome Biology
|March 19, 2016
Summary
This conference explored the latest advancements in next-generation immunology, focusing on the interplay between host genomics and the microbiome in shaping immunity during the genomic era.
Area of Science:
- Immunology
- Genomics
- Microbiome Research
Background:
- The conference highlighted the increasing integration of genomic data into immunological studies.
- Emphasis was placed on understanding host-microbiome interactions and their impact on immunity.
Framework:
- The event served as a platform for discussing cutting-edge research in the genomic era of immunology.
- It fostered interdisciplinary dialogue between immunologists, geneticists, and microbiologists.
Implementation:
- Presentations covered topics ranging from innate and adaptive immunity to host-pathogen interactions.
- Discussions included the application of next-generation sequencing technologies in immunological research.
Implications:
- The conference underscored the transformative potential of genomics and microbiome research in advancing immunological understanding.
- Future directions in immunology were shaped by the insights shared on host-genome-microbiome-immunity axis.
Related Concept Videos
The Oral Microbiota
9
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
9
Introduction to the Human Microbiota
29
Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
29
Gut-Brain Axis
31
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such...
31
Factors Affecting the Risk of Infection
14.6K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.6K
Functions of the Gut Microbiota
5
The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
5
Defense Against Bacterial Pathogens
3.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
3.4K

