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Sheathless Capillary Electrophoresis–Mass Spectrometry for Metabolic Profiling of Biological Samples
Published on: October 1, 2016
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Recent advances in capillary electrophoretic migration techniques for pharmaceutical analysis (2013-2015).
Sami El Deeb1, Hermann Wätzig1, Deia Abd El-Hady2,3
1Institute of Medicinal and Pharmaceutical Chemistry, TU Braunschweig, Braunschweig, Germany.
Electrophoresis
|March 19, 2016
Summary
This review highlights recent advancements in capillary electromigration techniques for pharmaceutical analysis, focusing on drug substances, chiral separations, and biopharmaceutical analysis from 2013-2015.
Area of Science:
- Analytical Chemistry
- Separation Science
Background:
- Capillary electromigration techniques have evolved significantly.
- Pharmaceutical analysis requires sensitive and robust methodologies.
Purpose of the Study:
- To review recent advancements in capillary electromigration for pharmaceutical analysis.
- To cover literature published between January 2013 and December 2015.
Main Methods:
- Discussion of quality by design principles.
- Analysis of sample injection methods and detection sensitivity.
- Review of chiral capillary electrophoresis (CE) and CE-MS applications.
Main Results:
- Recent progress in separation and analysis of drug-related substances.
- Advancements in chiral separations and their mass spectrometry coupling.
- Application of affinity capillary electrophoresis for receptor-ligand interactions.
Conclusions:
- Capillary electromigration offers versatile tools for pharmaceutical analysis.
- Continued development in methodologies enhances sensitivity and scope.
- Analysis of biopharmaceuticals remains a key area of application.
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