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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Disorders of Hemostasis01:24

Disorders of Hemostasis

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
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Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

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Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
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The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
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Structure and Function of Platelets01:18

Structure and Function of Platelets

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
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Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Characteristics and Functions of Blood01:26

Characteristics and Functions of Blood

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Blood is specialized connective tissue comprising about 8% of the body mass. It has a thick, liquid extracellular matrix that contains cells, dissolved proteins, and electrolytes, making it five times more viscous than water. Blood is warm, around 38°C, and has an alkaline pH ranging from 7.35 to 7.45.
The primary function of blood is to transport oxygen and carbon dioxide between tissues and the lungs. Oxygenated blood is bright red, while oxygen-depleted blood is darker. It also carries...
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Updated: Mar 24, 2026

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
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Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

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Blood drop patterns: Formation and applications.

Ruoyang Chen1, Liyuan Zhang1, Duyang Zang2

  • 1Department of Chemical Engineering, Monash University, Wellington Road, Clayton Campus, Victoria 3800, Australia.

Advances in Colloid and Interface Science
|March 19, 2016
PubMed
Summary
This summary is machine-generated.

Dried blood and plasma patterns reveal disease indicators. Analyzing these complex formations offers a potential low-cost diagnostic tool for human and livestock health, though mechanisms require further study.

Keywords:
AdhesionDried blood drop patternsSalt-induced drying patternsSessile drop evaporationTension-caused cracking patternsThe “coffee ring” effect

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Micro-particle Image Velocimetry for Velocity Profile Measurements of Micro Blood Flows
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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
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Micro-particle Image Velocimetry for Velocity Profile Measurements of Micro Blood Flows
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Micro-particle Image Velocimetry for Velocity Profile Measurements of Micro Blood Flows

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Area of Science:

  • Biophysics
  • Materials Science
  • Biomedical Diagnostics

Background:

  • Drying blood and plasma drops form complex patterns influenced by cellular and macromolecular interactions.
  • Disease-induced changes in blood components may alter dried drop patterns, suggesting diagnostic potential.
  • The underlying physicochemical forces driving pattern formation are not fully understood.

Purpose of the Study:

  • To review scientific advancements in microscopic observation and pattern interpretation of dried blood and plasma.
  • To explore the diagnostic applications of dried drop pattern analysis.
  • To elucidate the mechanisms behind pattern formation in dried blood and plasma.

Main Methods:

  • Microscopic observation of dried plasma and whole blood samples.
  • Analysis of pattern morphology, including cracks and fine structures.
  • Investigating the influence of environmental factors (humidity, substrate wettability) and drop size.
  • Applying engineering approaches to the evaporation process.

Main Results:

  • Plasma patterns show cracks and central fine structures, influenced by salts and proteins.
  • Whole blood patterns exhibit three characteristic zones, dependent on drying time.
  • Pattern formation is sensitive to environmental conditions and substrate properties.

Conclusions:

  • Dried drop patterns reflect the composition and health status of blood and plasma.
  • Pattern analysis holds promise as a simple diagnostic tool for health assessment.
  • Further research is needed to fully understand the complex physics governing pattern formation.