Related Experiment Video
Updated: Mar 24, 2026

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder
Published on: March 8, 2018
The Bidirectional Associations Between Psychotic Experiences and DSM-IV Mental Disorders
John J McGrath1, Sukanta Saha1, Ali Al-Hamzawi1
1From the Queensland Centre for Mental Health Research, Park Centre for Mental Health, Wacol, Australia; the Discipline of Psychiatry and the Queensland Brain Institute, University of Queensland, St. Lucia, Australia; the College of Medicine, Al-Qadisiya University, Diwania Governorate, Iraq; the Department and Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil; the Department of Epidemiologic and Psychosocial Research, National Institute of Psychiatry Ramon de la Fuente, Mexico City; the Department of Psychiatry, Stony Brook University School of Medicine, Stony Brook, N.Y.; the Centre for Mental Health, University of Melbourne, Melbourne, Australia; the Chronic Diseases Research Center (CEDOC) and the Department of Mental Health, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal; the Department of Health Care Policy, Harvard University, Boston; the Department of Psychiatry, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium; the Institute for Development, Research, Advocacy, and Applied Care (IDRAAC), Beirut, Lebanon; the National School of Public Health, Management, and Professional Development, Bucharest, Romania; IRCCS St. John of God Clinical Research Centre, IRCCS Centro S. Giovanni di Dio Fatebenefratelli, Brescia, Italy; the Department of Psychiatry, University College Hospital, Ibadan, Nigeria; Parc Sanitari Sant Joan de Deïu, CIBERSAM, Sant Boi de Llobregat, Barcelona, Spain; Trimbos-Instituut, Netherlands Institute of Mental Health and Addiction, Utrecht; the Shenzhen Insitute of Mental Health and Shenzhen Kanging Hospital, Shenzhen, China; Ecole des Hautes Etudes en Santé Publique (EHESP), Paris Descartes University, Paris; the Department of Psychological Medicine, Dunedin School of Medicine, University of Otago, New Zealand; IMIB-Arrixaca, CIBERESP-Murcia, Subdirección General de Salud Mental y Asistencia Psiquiátrica, Servicio Murciano de Salud, El Palmar (Murcia), Spain; Colegio Mayor de Cundinamarca University, Bogotá, Colombia; and the Department of Psychiatry, Virginia Commonwealth University, Richmond.
Psychotic experiences increase the risk of developing mental disorders. However, most mental disorders also elevate the risk of later psychotic experiences, suggesting a complex bidirectional relationship.
Area of Science:
- Psychiatry
- Epidemiology
- Mental Health Research
Background:
- Psychotic experiences are recognized risk factors for subsequent mental disorders.
- The reciprocal, time-lagged relationships between psychotic experiences and mental disorders require detailed investigation.
Purpose of the Study:
- To assess the bidirectional temporal associations between the first onset of psychotic experiences and mental disorders.
- To understand the time-lagged relationships using data from the World Health Organization World Mental Health Surveys.
Main Methods:
- Utilized data from 31,261 adult respondents across 18 countries in the World Mental Health (WMH) Surveys.
- Assessed lifetime prevalence and age at onset for psychotic experiences and 21 DSM-IV mental disorders.
- Employed discrete-time survival models to analyze bivariate and multivariate associations.
Main Results:
- First onsets of psychotic experiences predicted the subsequent onset of eight mental disorders, including major depressive disorder and bipolar disorder.
- Conversely, 18 of 21 primary mental disorders significantly predicted the subsequent onset of psychotic experiences.
- Odds ratios for mental disorders predicting psychotic experiences were generally higher than for psychotic experiences predicting mental disorders.
Conclusions:
- While psychotic experiences are linked to increased risk for several mental disorders, most mental disorders are associated with a higher risk of subsequent psychotic experiences.
- These findings highlight a complex, bidirectional relationship between psychotic experiences and mental disorders.
- Further research into the underlying factors of these temporal relationships is crucial for understanding the etiology of psychotic experiences.
Related Concept Videos
Diagnostic and Statistical Manual of Mental Disorders (DSM)
Dissociative Identity Disorder
Psychosis and Antipsychotic Drugs: Overview
Psychological and Sociocultural Causes of Schizophrenia
Positive Symptoms Schizophrenia: Hallucinations and Delusions
Hallucinations
Hallucinations in...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...

