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Basic fibroblast growth factor eluting microspheres enhance distraction enterogenesis.

Joshua D Rouch1, Andrew Scott1, Ziyad B Jabaji1

  • 1Department of Surgery, Division of Pediatric Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Journal of Pediatric Surgery
|March 21, 2016
PubMed
Summary

Basic fibroblast growth factor (bFGF) microspheres significantly enhanced intestinal regeneration in a rodent model of short bowel syndrome. This approach improved vascularity and nerve development, offering a promising new therapy for intestinal failure.

Keywords:
Basic fibroblast growth factorMechanical enterogenesisPLGA microspheresShort bowel syndrome

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Area of Science:

  • Regenerative Medicine
  • Gastroenterology
  • Biomaterials Science

Background:

  • Short bowel syndrome (SBS) is a malabsorptive condition often requiring complex management.
  • Distraction enterogenesis is a technique to lengthen the intestine.
  • Basic fibroblast growth factor (bFGF) promotes angiogenesis and tissue regeneration.

Purpose of the Study:

  • To evaluate distraction enterogenesis using polycaprolactone (PCL) springs combined with bFGF-loaded microspheres as a therapy for SBS.
  • To determine if bFGF enhances angiogenesis and intestinal regeneration during distraction enterogenesis.

Main Methods:

  • A 10-mm segment of rodent jejunum was isolated and fitted with a PCL spring.
  • Blank or bFGF-loaded microspheres were delivered to the jejunal segment.
  • After 4 weeks, segments were assessed for lengthening, vascularity, and neural development.

Main Results:

  • bFGF-loaded microspheres significantly increased microvascular density compared to blank microspheres.
  • Segments treated with bFGF showed increased submucosal and myenteric ganglia.
  • While overall lengthening was similar, bFGF increased luminal diameter.

Conclusions:

  • Sustained release bFGF microspheres enhance distraction enterogenesis by improving vascularity.
  • The combination of bFGF and distraction enterogenesis shows potential for treating short bowel syndrome.