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Serum Prolidase Activity as a Biomarker for Choroid Plexus Calcification
Suleyman Kaleli1, Dilcan Kotan, Mehmet Akdogan
1Department of Medical Biology, Medicine Faculty, Sakarya University.
The Tohoku Journal of Experimental Medicine
|March 23, 2016
Summary
Serum prolidase activity (SPA) is elevated in individuals with asymptomatic choroid plexus calcification (CPC). This finding suggests SPA may serve as a predictive biomarker for future neurological conditions, particularly in the context of brain calcification.
Area of Science:
- Neuroscience
- Biochemistry
- Radiology
Background:
- The choroid plexus (CP) is crucial for brain homeostasis, acting as the blood-cerebrospinal fluid barrier.
- Serum prolidase activity (SPA) is linked to collagen metabolism and may indicate fibrosis and inflammation.
- Choroid plexus calcification (CPC) is a common physiological finding, typically assessed via computed tomography (CT).
Purpose of the Study:
- To investigate the relationship between serum prolidase activity (SPA) and choroid plexus calcification (CPC).
- To determine if SPA can serve as a biomarker for the presence of CPC.
Main Methods:
- Compared SPA levels in 44 subjects with CPC (Hounsfield Units > 150) and 45 subjects with non-calcified CP (Hounsfield Units < 50).
- All subjects underwent neurological examination and CT scans; neurological examinations were normal.
- Analyzed correlations between SPA, vitamin D, and parathyroid hormone levels in the CPC group.
Main Results:
- Serum prolidase activity (SPA) was significantly higher in the choroid plexus calcification (CPC) group compared to the non-calcified CP group (p < 0.002).
- A significant positive correlation was observed between vitamin D and SPA levels within the CPC group.
- Vitamin D and parathyroid hormone levels were trended higher in the CPC group, but without statistical significance.
Conclusions:
- Serum prolidase activity (SPA) is a potential biomarker for choroid plexus calcification (CPC).
- Elevated SPA in asymptomatic CPC may predict future brain diseases.
- Further research is warranted to explore the predictive value of SPA in neurological disorders.
