Controlled release of curcumin from poly(HEMA-MAPA) membrane.

Area of Science:

• Polymer science and materials science
• Biomedical engineering
• Drug delivery systems

Background:

• Curcumin, a natural compound, possesses therapeutic potential for diseases and cancers.
• Developing effective drug delivery systems is crucial for optimizing curcumin's bioavailability and efficacy.
• Poly(HEMA-MAPA) offers a promising scaffold for controlled release applications.

Purpose of the Study:

• To synthesize and characterize poly(HEMA-MAPA) membranes for controlled drug delivery.
• To investigate the release kinetics of curcumin from these membranes under various conditions.
• To evaluate the potential of these membranes for therapeutic applications.

Main Methods:

• Membrane synthesis via UV-polymerization technique.
• Characterization using Scanning Electron Microscopy (SEM), Fourier-Transform Infrared Spectroscopy (FTIR), and swelling studies.
• Controlled release studies of curcumin at different pH and temperature conditions.

Main Results:

• Synthesized poly(HEMA-MAPA) membranes exhibited a highly porous structure.
• Optimal curcumin release of 70% was achieved at pH 7.4 and 37°C within 2 hours.
• Sustained curcumin release was observed over a 48-hour period, indicating slow release kinetics.

Conclusions:

• Poly(HEMA-MAPA) membranes are suitable for the controlled release of curcumin.
• The developed membranes demonstrate tunable drug release profiles based on environmental conditions.
• These findings support the potential of poly(HEMA-MAPA) membranes in drug delivery systems for curcumin therapy.