Modelling flavoenzymatic charge transfer events: development of catalytic indole deuteration strategies
Alexander T Murray1, Jonathan D Challinor1, Christina E Gulácsy1
1Department of Chemistry, University of Bath, Bath, BA2 7AY, UK. d.carbery@bath.ac.uk.
Abstract:
The formation and chemistry of flavin-indole charge transfer (CT) complexes has been studied using a model cationic flavin. The ability to form a CT complex is sensitive to indole structure as gauged by spectroscopic, kinetics and crystallographic studies. Single crystals of sufficient quality of a flavin-indole CT complex, suitable for X-ray diffraction, have been grown, allowing solid-state structural analysis. When CT complex formation is conducted in d4-methanol, an efficient and synthetically useful C-3 indole deuteration is observed.
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