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Drinking water and liver cancer
C C Ruan1, Y H Chen1, Z Q Zhang1
1Cui-Cai Ruan, Yan-Hua Chen, Zhen-Quan Zhang, Department of Chemistry and Mycology, Guangxi Cancer Institute, Nanning 530027, Guangxi Province, China.
World Journal of Gastroenterology
|March 24, 2016
Summary
Drinking pond water in high liver cancer incidence areas contains substances causing chromosomal aberrations. This mutagenicity is linked to increased liver cancer rates, suggesting water contaminants are a key factor.
Area of Science:
- Environmental Health
- Toxicology
- Cancer Epidemiology
Background:
- High incidence of liver cancer in Guangxi, China necessitates investigation into environmental risk factors.
- Drinking water quality is a potential contributor to public health issues in affected regions.
Purpose of the Study:
- To investigate the relationship between drinking water mutagenicity and liver cancer incidence in Guangxi.
- To identify specific water sources associated with increased mutagenic effects and cancer rates.
Main Methods:
- Analysis of 32 drinking water samples (pond, well, river, tap water) from a high liver cancer incidence area.
- Utilized the micronuclear technique in Vicia faba root tips to assess water mutagenicity.
- Correlated mutagenic effects with local liver cancer incidence data.
Main Results:
- Pond water and well water near ponds showed significant mutagenic effects, increasing micronucleus frequencies in Vicia faba.
- Well water, river water, and tap water did not exhibit significant mutagenic effects compared to controls.
- A positive correlation (r=0.86) was found between water mutagenicity and liver cancer incidence.
Conclusions:
- Drinking water, particularly pond water, in high liver cancer incidence areas contains agents causing chromosomal aberrations.
- The mutagenicity of drinking water is closely associated with the incidence of human liver cancer.
- Chemical mutagens in drinking water are implicated as a significant factor in the high rates of liver cancer.
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