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Related Experiment Video

Updated: Mar 23, 2026

Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function
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Matrix ageing and vascular impacts: focus on elastin fragmentation.

Laurent Duca1, Sébastien Blaise1, Béatrice Romier1

  • 1Team 2: Matrix aging and Vascular remodelling, UMR CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Université de Reims Champagne Ardenne (URCA), UFR Sciences Exactes et Naturelles, Reims, France.

Cardiovascular Research
|March 25, 2016
PubMed
Summary

Vascular ageing deteriorates blood vessels, increasing cardiovascular disease risk. Targeting elastin fragmentation and elastin-derived peptides offers new strategies to prevent or delay these age-related vascular complications.

Keywords:
AgeingElastin fragmentationExtracellular matrix remodellingVascular diseases

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Area of Science:

  • Biomedical science
  • Cardiovascular research
  • Aging research

Background:

  • Cardiovascular diseases (CVDs) are the leading global cause of death.
  • Increasing life expectancy leads to a growing aging population and rising CVD prevalence.
  • Vascular ageing, a normal aging process, involves progressive deterioration of blood vessel structure and function.

Purpose of the Study:

  • To review extracellular matrix (ECM) alterations during vascular ageing.
  • To focus on elastin fragmentation and its role in age-related vascular complications.
  • To discuss current and novel pharmacological strategies for vascular ageing.

Main Methods:

  • Literature review focusing on ECM, elastin, and collagen in vascular ageing.
  • Analysis of elastin fragmentation and elastin-derived peptides (EDP) in age-related vascular complications.
  • Discussion of pharmacological interventions targeting elastin degradation and EDP.

Main Results:

  • ECM ageing causes molecular alterations in proteins like elastin and collagen, impacting vascular diseases.
  • Elastin fragmentation and EDP generation are key contributors to age-related vascular complications.
  • Pharmacological strategies can minimize elastin degradation and associated biological effects.

Conclusions:

  • Understanding ECM alterations in vascular ageing is crucial for addressing CVD.
  • Targeting elastin fragmentation and EDP offers potential therapeutic avenues.
  • Pharmacological strategies may prevent or delay vascular ageing and its complications.