Troponin T in Patients with Traumatic Chest Injuries with and without Cardiac Involvement: Insights from an
Ismail Mahmood1, Ayman El-Menyar2, Wafer Dabdoob3
1Department of Surgery, Section of Trauma Surgery, Hamad General Hospital, Doha, Qatar.
North American Journal of Medical Sciences
|March 25, 2016
Summary
Elevated serum troponin T (TnT) in traumatic chest injury (TCI) patients indicates worse outcomes, even without cardiac involvement. Positive TnT reflects injury severity and predicts mortality in these critical cases.
Area of Science:
- Trauma Surgery
- Cardiology
- Emergency Medicine
Background:
- Serum troponin T (TnT) is a key biomarker for myocardial injury.
- The significance of elevated TnT in traumatic chest injury (TCI) without apparent cardiac involvement is not well understood.
Purpose of the Study:
- To investigate the implications of positive TnT in TCI patients, irrespective of cardiac involvement.
- To identify predictors of TnT positivity and mortality in TCI patients.
Main Methods:
- Retrospective analysis of TCI patients from 2008-2011.
- Comparison of patients with positive TnT (Group 1) versus negative TnT (Group 2).
- Multivariate regression analyses to determine predictors of TnT positivity and mortality.
Main Results:
- 19.3% of TCI patients had positive TnT.
- Positive TnT was associated with younger age, more severe injuries (higher ISS and chest AIS), longer hospital stays, and increased need for interventions like mechanical ventilation.
- Positive TnT predicted hospital mortality, even in patients without clinical cardiac involvement.
Conclusions:
- Elevated TnT is common in blunt TCI and associated with poorer outcomes, particularly in polytrauma.
- Positive TnT serves as an indicator of overall injury severity, including extrathoracic injuries.
- Further prospective research is recommended to fully elucidate the role of TnT in TCI.
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