Related Experiment Video
Updated: Mar 23, 2026
A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program
Published on: April 19, 2019
KNOW-Ped CKD (KoreaN cohort study for outcomes in patients with pediatric CKD): Design and methods
Hee Gyung Kang1, Hyun Jin Choi1, Kyung Hee Han2
1Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea.
Insights
The KoreaN cohort study for Outcome in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD) aims to improve understanding of pediatric chronic kidney disease (CKD) in Asia. This research will provide crucial data for better management strategies for children with CKD.
Area of Science:
- Nephrology
- Pediatric Medicine
- Epidemiology
Background:
- Global prevalence of chronic kidney disease (CKD) is rising, particularly impacting children's growth and development.
- Pediatric CKD presents unique etiologies and requires aggressive management to prevent progression and complications.
- The KNOW-Ped CKD study was initiated to enhance understanding and management of Asian pediatric CKD patients.
Purpose of the Study:
- To conduct a nationwide, prospective, observational cohort study on pediatric CKD in Korea.
- To gather comprehensive data on clinical findings, follow-up, and bio-specimens from pediatric CKD patients.
- To improve the understanding and clinical management of Asian pediatric patients diagnosed with CKD.
Main Methods:
- Recruitment of 450 patients under 20 years old across seven major centers.
- Inclusion of patients with CKD stages I to V for comprehensive assessment.
- Structured follow-up and bio-specimen collection for detailed analysis.
Main Results:
- Primary endpoints: CKD progression (50% estimated glomerular filtration rate decline) and need for renal replacement therapy or death.
- Secondary outcomes: development of left ventricular hypertrophy, hypertension, growth impairment, neuropsychological and behavioral status, kidney growth, and quality of life.
- Data collection ongoing for comprehensive analysis of pediatric CKD progression and outcomes.
Conclusions:
- The KNOW-Ped CKD study is expected to yield significant insights into pediatric CKD.
- Findings will inform evidence-based strategies for improved patient management and outcomes.
- This research aims to translate new knowledge into enhanced clinical care for children with CKD.
Background:
The global prevalence of chronic kidney disease (CKD) is increasing. In children, CKD exhibits unique etiologies and can have serious impacts on children's growth and development. Therefore, an aggressive approach to preventing the progression of CKD and its complications is imperative. To improve the understanding and management of Asian pediatric patients with CKD, we designed and launched KNOW-Ped CKD (KoreaN cohort study for Outcome in patients With Pediatric Chronic Kidney Disease), a nationwide, prospective, and observational cohort study of pediatric CKD with funding from the Korean government.
Methods/Design:
From seven major centers, 450 patients <20 years of age with CKD stages I to V are recruited for the comprehensive assessment of clinical findings, structured follow-up, and bio-specimen collection. The primary endpoints include CKD progression, defined as a decline of estimated glomerular filtration rate by 50 %, and a requirement for renal replacement therapy or death. The secondary outcomes include the development of left ventricular hypertrophy or hypertension, impairment of growth, neuropsychological status, behavioral status, kidney growth, and quality of life.
Discussion:
With this study, we expect to obtain more information on pediatric CKD, which can be translated to better management for the patients.
Trial Registration:
NCT02165878 (ClinicalTrials.gov), submitted on June 11, 2014.
Related Concept Videos
01:20Study Designs in Epidemiology
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
01:28Chronic Kidney Disease III: Interprofessional Care
01:15Study Design in Statistics
Does aspirin reduce the risk of heart attacks? Is one brand of fertilizer more effective at growing roses than another? Is fatigue as dangerous to a driver as the influence of alcohol? Questions like these are answered using randomized experiments with proper...
01:12Analysis of Population Pharmacokinetic Data
01:25Chronic Kidney Disease I: Introduction
01:16Crossover Experiments
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.