Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

5.8K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
5.8K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.8K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.8K
Whole Body Regeneration01:33

Whole Body Regeneration

4.4K
Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
4.4K
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

2.8K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.8K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.3K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polygenic risk score analysis of noise-induced hearing loss: An integrated cross-sectional and longitudinal study.

Hearing research·2026
Same author

Lineage tracing in human cortical development.

Current opinion in genetics & development·2026
Same author

Myeloid-specific interferon regulatory factor 5 promotes bone formation via orchestration of osteoclast lineage-osteoblast coupling.

The Journal of biological chemistry·2026
Same author

Effects of light-shielding treatment on the quality and flavor of 'Ziyan' tea wine during storage: Insights from color, taste, and aroma.

Food chemistry·2026
Same author

The leaked mitochondrial DNA activated the cGAS-STING signaling pathway and exacerbated the motor dysfunction in mice caused by MPTP.

Experimental neurology·2026
Same author

Molecular Engineering of Nicotinamide Riboside Kinase and Process Optimization for Efficient Nicotinamide Mononucleotide Production.

Foods (Basel, Switzerland)·2026
Same journal

How best to measure tear film formation: an opinion.

Frontiers in physiology·2026
Same journal

Effects of heart rate on cardiac function in normal mice and rats and in animal models of heart failure.

Frontiers in physiology·2026
Same journal

When mitochondria lose their fold: matrix proteostasis and stress signaling.

Frontiers in physiology·2026
Same journal

Specific collagen peptides supplementation increases collagen type I content in skeletal muscle after 12 weeks of high-load resistance training: a randomized controlled trial.

Frontiers in physiology·2026
Same journal

Impulse oscillometry with quantitative computed tomography provides additional clinical information beyond spirometry in chronic airflow obstruction: a pilot study.

Frontiers in physiology·2026
Same journal

Photoperiod effects on growth, lipid metabolism, and lipidomics analysis of tilapia.

Frontiers in physiology·2026
See all related articles

Related Experiment Video

Updated: Mar 23, 2026

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells
03:45

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells

Published on: May 5, 2023

3.5K

Pulp Regeneration: Current Approaches and Future Challenges.

Jingwen Yang1, Guohua Yuan1, Zhi Chen2

  • 1The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan UniversityWuhan, China; Department of Pediatric Dentistry, School and Hospital of Stomatology, Wuhan UniversityWuhan, China.

Frontiers in Physiology
|March 26, 2016
PubMed
Summary
This summary is machine-generated.

Regenerative endodontics revitalizes teeth by regenerating pulp-like tissues using a cell homing strategy. Key preconditions include root canal disinfection and optimal apical foramen size for successful pulp regeneration.

Keywords:
cell homingregenerative endodonticsroot canal disinfectionsignaling moleculesstem cells

More Related Videos

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
07:07

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

12.0K
Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models
05:16

Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models

Published on: October 27, 2023

2.0K

Related Experiment Videos

Last Updated: Mar 23, 2026

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells
03:45

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells

Published on: May 5, 2023

3.5K
Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
07:07

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

12.0K
Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models
05:16

Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models

Published on: October 27, 2023

2.0K

Area of Science:

  • Dental Regenerative Medicine
  • Endodontics
  • Tissue Engineering

Background:

  • Regenerative endodontics aims to replace damaged pulp tissue, restoring tooth vitality and improving patient quality of life.
  • Pulp revascularization shows promise for clinical application through cell homing strategies.
  • Functional regenerated pulp requires vascularization, re-innervation, and regulated dentin deposition.

Purpose of the Study:

  • This review focuses on the essential preconditions and cell homing strategies for pulp regeneration.
  • To explore advancements in root canal disinfection techniques.
  • To examine the role of signaling molecules in recruiting endogenous cells for pulp regeneration.

Main Methods:

  • Advanced root canal disinfection methods include antibiotics, negative-pressure irrigation, and laser/ultrasonic irradiation.
  • Signaling molecules such as SDF-1α, bFGF, PDGF, SCF, and G-CSF are employed for cell homing.
  • Studies investigate optimal apical foramen size, with regeneration possible for foramina <1 mm.

Main Results:

  • Successful pulp regeneration is contingent upon effective root canal disinfection and appropriate apical foramen size.
  • Cell homing strategies utilizing specific signaling molecules facilitate the formation of pulp-like tissues.
  • The recruitment of endogenous stem cells offers a promising avenue for clinical translation.

Conclusions:

  • Regenerative endodontics holds significant potential for revitalizing teeth.
  • Optimizing root canal disinfection and understanding apical foramen size are crucial for successful outcomes.
  • Cell homing strategies represent a novel and promising approach for dental pulp regeneration.