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Updated: Mar 23, 2026
08:50
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
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[COMBINATION OF TAURINE WITH ZINC DIASPARTATE FOR CORRECTION OF METABOLISM DISTURBANSES IN NEPHRONS AND RENAL
Eksperimental'Naia I Klinicheskaia Farmakologiia
|March 29, 2016
Summary
The taurine and zinc diaspartate combination (taucin) demonstrated dose-dependent nephroprotective effects in rats. This study investigated taucin
Area of Science:
- Pharmacology
- Nephrology
- Toxicology
Context:
- Contrast-induced nephropathy (CIN) is a significant clinical concern.
- Iodinated contrast media can induce kidney damage.
- Investigating protective agents against CIN is crucial.
Purpose:
- To evaluate the nephroprotective potential of taurine combined with zinc diaspartate (taucin).
- To assess the dose-dependent efficacy of taucin in a rat model of CIN.
- To determine the protective effects of taucin against contrast media-induced kidney injury.
Summary:
- Rats were administered taucin (taurine and zinc diaspartate) at doses of 250 and 500 mg/kg for 14 days.
- Contrast-induced nephropathy was induced using sodium and meglumin amidotrizoates.
- The combination treatment showed a dose-dependent reduction in kidney damage.
Impact:
- Findings suggest taucin as a potential therapeutic strategy for preventing CIN.
- This research contributes to understanding the renoprotective mechanisms of taurine and zinc.
- Further studies may explore clinical applications of taucin for CIN prevention.
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