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Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing

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Acyclovir-loaded sorbitan esters-based organogel: development and rheological characterization.

Kuldeep Rajpoot^1,2

¹a Pharmaceutical Research Project Laboratory, Department of Pharmaceutical Sciences , Dr. Hari Singh Gour Vishwavidyalaya , Sagar , Madhya Pradesh , India.

Artificial Cells, Nanomedicine, and Biotechnology

|March 29, 2016

Summary

This study developed a novel nanoemulsion-based organogel (NEOG) for topical acyclovir delivery to treat herpes simplex virus infections, showing promising sustained and site-specific drug release.

Keywords:

Acyclovir herpes simplex virus isopropyl myristate nanoemulsion organogel rheology sorbitan monostearate topical

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Area of Science:

Pharmaceutical Sciences
Drug Delivery Systems
Dermatology

Background:

Herpes simplex virus (HSV) infections require effective topical treatments.
Nanoemulsion-based organogels (NEOGs) offer potential for enhanced topical drug delivery.
Acyclovir is a common antiviral medication for HSV.

Purpose of the Study:

To develop and characterize a NEOG system loaded with acyclovir for topical HSV treatment.
To evaluate the gelling properties and drug release characteristics of the NEOG system.

Main Methods:

Formulation of NEOG using pseudo-ternary phase diagrams.
Rheological characterization (storage modulus G', loss modulus G″).
Determination of gel-sol transition temperature (Tg) and fractal dimension (Df).

Main Results:

The NEOG system demonstrated an increased non-birefringent, optically isotropic region with varying Smix (Kw) ratios.
NEOG C exhibited favorable rheological properties and compact network structures.
Increased density of the tubular network was observed with Kw, indicated by Tg and Df.

Conclusions:

The developed NEOG system possesses high gelling ability for sustained and site-specific acyclovir delivery.
This NEOG formulation shows potential for effective topical treatment of herpes simplex virus infections.