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Updated: Aug 11, 2026
Production and Detection of Reactive Oxygen Species ROS in Cancers
Published on: November 21, 2011
Generation of Reactive Oxygen Species in Peripheral Blood Lymphocytes of Patients with Prostate Cancer
A K Grekhova1, L B Gorbacheva2
1N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia. annagrekhova1@gmail.com.
Abstract:
The study revealed a two-fold elevation of ROS production in peripheral blood lymphocytes of the patients with prostate cancer (from 0.48±0.04 to 0.93±0.12 rel. units) together with significant variability of individual values. Hormone therapy had no effect on the mean and individual ROS levels. In contrast, organometallic cytostatics cisplatin and morfozol 2-fold increased ROS generation in lymphocytes of patients with prostate cancer above the enhanced level of this parameter determined by tumor growth.
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