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Interleukin-1β Can Reduce Manifestations of Delayed Effects of Prolonged Exposure to Low-Intensity γ-Radiation
N Yu Vorobyeva1, A K Grekhova2, K Yu Trubitsina3
1Laboratory of Radiation Biophysics, A. I. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency, Moscow, Russia. nuv.rad@mail.ru.
Abstract:
We showed that injection of IL-1β (Betaleukin) in a dose of 3 μg/kg 22 h before prolonged (21 h) exposure to low-intensity (10 mGy/min) γ-radiation in a dose of 12.6 Gy reduced the number of double-strand DNA breaks in murine spleen cells to the control level in 4 months after exposure and the number of double-strand DNA breaks induced by additional acute irradiation in a dose of 6 Gy. The results suggest that IL-1β can improve the efficiency of systems reducing the number of double-strand DNA breaks in murine spleen cells at delayed terms after exposure to prolonged low-intensity radiation.
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