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Effect of 5-Fluorouracil on Thymidine Phosphorylase Activity in Model Experiment
M A Stashkevich1, E V Khomutov1, Yu V Dumanskii1
1Central Research Laboratory, M. Gorky Donetsk National Medical University, Donetsk, Ukraine.
Bulletin of Experimental Biology and Medicine
|March 30, 2016
Abstract:
Variations in thymidine phosphorylase activity in rat liver were studied in 1, 3, 6, 12, and 24 h after intraperitoneal bolus injection of 5-fluorouracil. Enzyme activity was measured by HPLC. A 2-fold decrease in enzyme activity was observed 3 h after 5-fluorouracil administration and persisted for 12 h. This additional effect of the cytostatic should be taken into account in choosing chemotherapy protocol.

