Related Experiment Video
Updated: Mar 23, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
Cells of Benign and Borderline Thyroid Tumor Express Malignancy Markers
A Yu Abrosimov1,2, N Yu Dvinskikh3, A V Sidorin3
1Endocrinology Research Center, Ministry of Health of the Russian Federation, Moscow, Russia. abrosim@mrrc.obninsk.ru.
Abstract:
We studied expression of malignancy markers galectin-3, cytokeratin-19, HBME-1, fibronectin, and cyclin D1 in cells of benign (n=51), malignant (n=87), and borderline (n=53) tumors. The results indicate that 3.9% benign and 41.5% borderline tumors express malignancy markers (specificity 98-100%). Follow up over 1-10 years after surgical treatment for borderline tumors showed no progression of tumor growth. We conclude that some benign and borderline tumors represent low-grade neoplasms with favorable prognosis.
Related Concept Videos
Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Abnormal Proliferation
Mitogens and the Cell Cycle

