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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
[Management of benign melanocytic lesions as a melanoma prevention. Systematic review]
Renata Linertová1, Cristina Valcárcel-Nazco1, Juan Ramón Lacalle-Remigio2
1Fundación Canaria de Investigación Sanitaria (FUNCANIS), Las Palmas de Gran Canaria, Las Palmas, España; Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), España; Centro de Investigación Biomédica de Canarias (CIBICAN), Campus Ciencias de La Salud, La Laguna, Santa Cruz de Tenerife, España.
Abstract:
There is a growing concern and awareness of skin cancer. As a result, possibly unnecessary surgeries of melanocytic lesions are carried out as a prophylactic measure. We performed a systematic review of the medical literature to identify primary studies on the effectiveness and cost-effectiveness of surgery treatment of benign melanocytic lesions for melanoma prevention. We included 19 primary studies on surgical treatment of acquired melanocytic lesions and one economic evaluation. Indicators, such as number needed to treat and the malignancy ratio, depend on several factors such as specialty and experience of the physician, pressure from the patient or patient characteristics. Early diagnosis of melanoma is critical in preventing skin cancer. However, primary studies show through several indicators that there are factors that increase the proportion of lesions treated unnecessarily. Effectiveness can be improved by careful use of techniques to identify suspicious lesions and educational programs for physicians, especially in primary care.
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