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New Finding in Vernal Keratoconjunctivitis: Splendore-Hoeppli Phenomenon
Mohammad Soleimani1, Seyed Ali Tabatabaei, Reza Mirshahi
1Eye Research Center, Ocular Trauma and Emergency Unit, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Cornea
|March 31, 2016
Summary
The Splendore-Hoeppli phenomenon, a rare finding, can manifest late in vernal keratoconjunctivitis (VKC). This study shows successful treatment of these VKC-related nodules with corticosteroids and cyclosporine.
Area of Science:
- Ophthalmology
- Histopathology
Background:
- Vernal keratoconjunctivitis (VKC) is a chronic allergic eye condition.
- The Splendore-Hoeppli phenomenon is a rare histopathologic finding.
Observation:
- Two young women presented with subconjunctival nodules.
- These nodules were identified as a manifestation of the Splendore-Hoeppli phenomenon.
- Both patients had a history of severe VKC.
Findings:
- After excluding other causes, patients received topical corticosteroids.
- One patient also received topical cyclosporine 2%.
- Complete resolution of the nodules was observed in both cases.
Implications:
- The Splendore-Hoeppli phenomenon can be a late clinical manifestation of VKC.
- This finding expands the known clinical spectrum of VKC.
- Topical corticosteroids and cyclosporine are effective treatments.
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