Related Experiment Video
Updated: Mar 23, 2026
16:56
Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
Published on: August 30, 2014
17.8K
[Dengue vaccines. A reality for Argentina?]
Pablo W Orellano1, Oscar D Salomón2
1Universidad Tecnológica Nacional, Facultad Regional San Nicolás, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
Medicina
|March 31, 2016
Summary
Dengue vaccines show promise for Argentina, but implementation requires careful planning. A risk-stratified approach targeting high-risk populations is recommended for cost-effective dengue prevention.
Area of Science:
- Epidemiology of infectious diseases
- Vaccinology and immunology
- Public health policy
Context:
- Argentina faces recurring dengue outbreaks annually since 1998.
- Several candidate dengue vaccines have undergone testing in endemic regions.
- One advanced dengue vaccine is approved for individuals over nine years old in three Latin American countries.
Purpose:
- To analyze the benefits and drawbacks of dengue vaccines.
- To discuss challenges in implementing a vaccination strategy in Argentina.
- To propose a risk stratification model for targeted vaccination programs.
Summary:
- The article evaluates dengue vaccines, considering their advantages, disadvantages, and implementation hurdles in Argentina.
- A novel risk stratification strategy is proposed, focusing on high-transmission areas and individuals at risk of severe dengue.
- Local realities should inform endemicity definitions and vaccination program planning.
Impact:
- Provides evidence-based recommendations for incorporating dengue vaccines into national immunization programs.
- Suggests a cost-effective approach to dengue vaccine deployment by targeting specific subpopulations.
- Aims to inform public health policy for improved dengue control in Argentina.
Related Concept Videos
01:51Vaccinations
53.5K
Overview
53.5K
01:21Vaccines
29
Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the...
29
01:25Arboviral Encephalitis
8
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
8
00:42Cross-reactivity
33.8K
Overview
33.8K
01:23Vaccine Production
30
Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
30
01:27Influenza
36
Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
36